Hepatitis C virus RNA is 5’ capped with flavin adenine dinucleotide (FAD)

RNA viruses have evolved elaborate strategies for protection of their genomes, including 5’ capping. However, so far no RNA 5’ cap was identified for hepatitis C virus (HCV) (1,2), which causes chronic infection, liver cirrhosis and cancer(3). Here, we demonstrate that the cellular metabolite flavin...

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Publicado no:Nature
Main Authors: Sherwood, Anna V., Rivera-Rangel, Lizandro R., Ryberg, Line A., Larsen, Helena S., Anker, Klara M., Costa, Rui, Vågbø, Cathrine B., Jakljevič, Eva, Pham, Long V., Fernandez-Antunez, Carlota, Indrisiunaite, Gabriele, Podolska-Charlery, Agnieszka, Grothen, Julius E.R., Langvad, Nicklas W., Fossat, Nicolas, Offersgaard, Anna, Al-Chaer, Amal, Nielsen, Louise, Kuśnierczyk, Anna, Sølund, Christina, Weis, Nina, Gottwein, Judith M., Holmbeck, Kenn, Bottaro, Sandro, Ramirez, Santseharay, Bukh, Jens, Scheel, Troels K.H., Vinther, Jeppe
Formato: Artigo
Idioma:Inglês
Publicado em: 2023
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616780/
https://ncbi.nlm.nih.gov/pubmed/37407817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-023-06301-3
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