Hepatitis C virus RNA is 5’ capped with flavin adenine dinucleotide (FAD)

RNA viruses have evolved elaborate strategies for protection of their genomes, including 5’ capping. However, so far no RNA 5’ cap was identified for hepatitis C virus (HCV) (1,2), which causes chronic infection, liver cirrhosis and cancer(3). Here, we demonstrate that the cellular metabolite flavin...

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Published in:Nature
Main Authors: Sherwood, Anna V., Rivera-Rangel, Lizandro R., Ryberg, Line A., Larsen, Helena S., Anker, Klara M., Costa, Rui, Vågbø, Cathrine B., Jakljevič, Eva, Pham, Long V., Fernandez-Antunez, Carlota, Indrisiunaite, Gabriele, Podolska-Charlery, Agnieszka, Grothen, Julius E.R., Langvad, Nicklas W., Fossat, Nicolas, Offersgaard, Anna, Al-Chaer, Amal, Nielsen, Louise, Kuśnierczyk, Anna, Sølund, Christina, Weis, Nina, Gottwein, Judith M., Holmbeck, Kenn, Bottaro, Sandro, Ramirez, Santseharay, Bukh, Jens, Scheel, Troels K.H., Vinther, Jeppe
Format: Artigo
Language:Inglês
Published: 2023
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7616780/
https://ncbi.nlm.nih.gov/pubmed/37407817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-023-06301-3
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