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Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

Hepatitis C virus (HCV) infection is a leading cause of chronic liver diseases worldwide, but treatment options are limited. Basic HCV research required for vaccine and drug development has been hampered by inability to culture patient isolates, and to date only the JFH1 (genotype 2a) recombinant re...

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Detalhes bibliográficos
Main Authors: Li, Yi-Ping, Ramirez, Santseharay, Gottwein, Judith M., Scheel, Troels K. H., Mikkelsen, Lotte, Purcell, Robert H., Bukh, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3344947/
https://ncbi.nlm.nih.gov/pubmed/22467829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203829109
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