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Peptidic boronic acid Plasmodium falciparum SUB1 inhibitors with improved selectivity over human proteasome
Plasmodium falciparum subtilisin-like serine protease 1 (PfSUB1) is essential for egress of invasive merozoite forms of the parasite, rendering PfSUB1 an attractive antimalarial target. Here we report studies aimed to improve drug-like properties of peptidic boronic acid PfSUB1 inhibitors including...
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| Publié dans: | J Med Chem |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2024
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7616463/ https://ncbi.nlm.nih.gov/pubmed/39051854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.4c01005 |
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