Timed use of digoxin prevents heart ischemia-reperfusion injury through a REV-ERBα-UPS signaling pathway

Myocardial ischemia-reperfusion injury (MIRI) induces life-threatening damages to the cardiac tissue and pharmacological means to achieve cardioprotection are sorely needed. MIRI severity varies along the day-night cycle and is molecularly linked to components of the cellular clock including the nuc...

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Pubblicato in:Nat Cardiovasc Res
Autori principali: Vinod, Manjula, Berthier, Alexandre, Maréchal, Xavier, Gheeraert, Céline, Boutry, Raphaёl, Delhaye, Stéphane, Annicotte, Jean-Sébastien, Duez, Hélène, Hovasse, Agnès, Cianférani, Sarah, Montaigne, David, Eeckhoute, Jérôme, Staels, Bart, Lefebvre, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2022
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615528/
https://ncbi.nlm.nih.gov/pubmed/38229609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s44161-022-00148-z
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