Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex

The nuclear receptor REV-ERBα integrates the circadian clock with hepatic glucose and lipid metabolism by nucleating transcriptional comodulators at genomic regulatory regions. An interactomic approach identified O-GlcNAc transferase (OGT) as a REV-ERBα−interacting protein. By shielding cytoplasmic...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Berthier, Alexandre, Vinod, Manjula, Porez, Geoffrey, Steenackers, Agata, Alexandre, Jérémy, Yamakawa, Nao, Gheeraert, Céline, Ploton, Maheul, Maréchal, Xavier, Dubois-Chevalier, Julie, Hovasse, Agnès, Schaeffer-Reiss, Christine, Cianférani, Sarah, Rolando, Christian, Bray, Fabrice, Duez, Hélène, Eeckhoute, Jérôme, Lefebvre, Tony, Staels, Bart, Lefebvre, Philippe
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2018
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255172/
https://ncbi.nlm.nih.gov/pubmed/30397120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805397115
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