Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes

Various small molecules have been used as functional probes for tissue imaging in medical diagnosis and pharmaceutical drugs for disease treatment. The spatial distribution, target selectivity, and diffusion/excretion kinetics of small molecules in structurally complicated specimens are critical for...

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Bibliografiska uppgifter
I publikationen:Chem
Huvudupphovsmän: Nonaka, Hiroshi, Mino, Takeharu, Sakamoto, Seiji, Oh, Jae Hoon, Watanabe, Yu, Ishikawa, Mamoru, Tsushima, Akihiro, Amaike, Kazuma, Kiyonaka, Shigeki, Tamura, Tomonori, Aricescu, A. Radu, Kakegawa, Wataru, Miura, Eriko, Yuzaki, Michisuke, Hamachi, Itaru
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2023
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615374/
https://ncbi.nlm.nih.gov/pubmed/38094901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chempr.2022.11.005
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