Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes

Various small molecules have been used as functional probes for tissue imaging in medical diagnosis and pharmaceutical drugs for disease treatment. The spatial distribution, target selectivity, and diffusion/excretion kinetics of small molecules in structurally complicated specimens are critical for...

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Detalhes bibliográficos
Publicado no:Chem
Main Authors: Nonaka, Hiroshi, Mino, Takeharu, Sakamoto, Seiji, Oh, Jae Hoon, Watanabe, Yu, Ishikawa, Mamoru, Tsushima, Akihiro, Amaike, Kazuma, Kiyonaka, Shigeki, Tamura, Tomonori, Aricescu, A. Radu, Kakegawa, Wataru, Miura, Eriko, Yuzaki, Michisuke, Hamachi, Itaru
Formato: Artigo
Idioma:Inglês
Publicado em: 2023
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615374/
https://ncbi.nlm.nih.gov/pubmed/38094901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chempr.2022.11.005
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