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Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent

The ability to incorporate a desired functionality into proteins of interest in a site-specific manner can provide powerful tools for investigating biological systems and creating therapeutic conjugates. However, there are not any universal methods that can be applied to all proteins, and it is thus...

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Foilsithe in:Bioorg Med Chem
Main Authors: Thimaradka, Vikram, Oh, Jae Hoon, Heroven, Christina, Aricescu, A. Radu, Yuzaki, Michisuke, Tamura, Tomonori, Hamachi, Itaru
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610637/
https://ncbi.nlm.nih.gov/pubmed/33360195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115947
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