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A comparison of different population-level summary measures for randomised trials with time-to-event outcomes, with a focus on non-inferiority trials

BACKGROUND: The population-level summary measure is a key component of the estimand for clinical trials with time-to-event outcomes. This is particularly the case for non-inferiority trials, because different summary measures imply different null hypotheses. Most trials are designed using the hazard...

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Detalhes bibliográficos
Publicado no:Clin Trials
Main Authors: Quartagno, Matteo, Morris, Tim P, Gilbert, Duncan C, Langley, Ruth E, Nankivell, Matthew G, Parmar, Mahesh KB, White, Ian R
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2023
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7615295/
https://ncbi.nlm.nih.gov/pubmed/37337728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/17407745231181907
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