Handling an uncertain control group event risk in non-inferiority trials: non-inferiority frontiers and the power-stabilising transformation

BACKGROUND: Non-inferiority trials are increasingly used to evaluate new treatments that are expected to have secondary advantages over standard of care, but similar efficacy on the primary outcome. When designing a non-inferiority trial with a binary primary outcome, the choice of effect measure fo...

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Detalles Bibliográficos
Publicado en:Trials
Main Authors: Quartagno, Matteo, Walker, A. Sarah, Babiker, Abdel G., Turner, Rebecca M., Parmar, Mahesh K. B., Copas, Andrew, White, Ian R.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
Assuntos:
Methodology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7006194/
https://ncbi.nlm.nih.gov/pubmed/32029000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-020-4070-4
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