Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Metastasis is the primary cause of cancer-related mortality. Tumor cell interactions with cells of the vessel wall are decisive and potentially rate-limiting for metastasis. The molecular nature of this crosstalk is beyond candidate gene approaches hitherto poorly understood. Employing endothelial c...

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Udgivet i:Sci Transl Med
Main Authors: Singhal, Mahak, Gengenbacher, Nicolas, Pari, Ashik Ahmed Abdul, Kamiyama, Miki, Hai, Ling, Kuhn, Bianca J., Kallenberg, David M., Kulkarni, Shubhada R., Camilli, Carlotta, Preuß, Stephanie F., Leuchs, Barbara, Mogler, Carolin, Espinet, Elisa, Besemfelder, Eva, Heide, Danijela, Heikenwalder, Mathias, Sprick, Martin R., Trumpp, Andreas, Krijgsveld, Jeroen, Schlesner, Matthias, Hu, Junhao, Moss, Stephen E., Greenwood, John, Augustin, Hellmut G.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614902/
https://ncbi.nlm.nih.gov/pubmed/34516824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abe6805
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