LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency

BACKGROUND: A poorly functioning tumor vasculature is pro-oncogenic and may impede the delivery of therapeutics. Normalizing the vasculature, therefore, may be beneficial. We previously reported that the secreted glycoprotein leucine-rich a-2-glycoprotein 1 (LRG1) contributes to pathogenic neovascul...

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Publicado no:Med
Main Authors: O’Connor, Marie N., Kallenberg, David M., Camilli, Carlotta, Pilotti, Camilla, Dritsoula, Athina, Jackstadt, Rene, Bowers, Chantelle E., Watson, H. Angharad, Alatsatianos, Markella, Ohme, Julia, Dowsett, Laura, George, Jestin, Blackburn, Jack W.D., Wang, Xiaomeng, Singhal, Mahak, Augustin, Hellmut G., Ager, Ann, Sansom, Owen J., Moss, Stephen E., Greenwood, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614757/
https://ncbi.nlm.nih.gov/pubmed/35590198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.medj.2021.10.002
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