Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis

Metastasis is the primary cause of cancer-related mortality. Tumor cell interactions with cells of the vessel wall are decisive and potentially rate-limiting for metastasis. The molecular nature of this crosstalk is beyond candidate gene approaches hitherto poorly understood. Employing endothelial c...

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Publicat a:Sci Transl Med
Autors principals: Singhal, Mahak, Gengenbacher, Nicolas, Pari, Ashik Ahmed Abdul, Kamiyama, Miki, Hai, Ling, Kuhn, Bianca J., Kallenberg, David M., Kulkarni, Shubhada R., Camilli, Carlotta, Preuß, Stephanie F., Leuchs, Barbara, Mogler, Carolin, Espinet, Elisa, Besemfelder, Eva, Heide, Danijela, Heikenwalder, Mathias, Sprick, Martin R., Trumpp, Andreas, Krijgsveld, Jeroen, Schlesner, Matthias, Hu, Junhao, Moss, Stephen E., Greenwood, John, Augustin, Hellmut G.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614902/
https://ncbi.nlm.nih.gov/pubmed/34516824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.abe6805
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