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A Divergent Polyene Cyclization for the Total Synthesis of Greenwayodendrines, Greenwaylactams, Polysin and Polyveoline

We present a concise (5–8 steps) asymmetric total synthesis of nine sesquiterpenoid alkaloids featuring four different tetra-/pentacyclic scaffolds. To this end, a novel, bioinspired indole N-terminated cationic tricyclization has been developed enabling the divergent synthesis of greenwayodendrines...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Plangger, Immanuel, Pinkert, Tobias, Wurst, Klaus, Magauer, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2023
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614870/
https://ncbi.nlm.nih.gov/pubmed/37318945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202307719
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