Differential nanoscale organisation of LFA-1 modulates T cell migration

Effector T-cells rely on integrins to drive adhesion and migration to facilitate their immune function. Heterodimeric transmembrane integrin LFA-1 (αLβ2) regulates adhesion and migration of effector T cells through linkage of the extracellular matrix with the intracellular actin treadmill machinery....

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Bibliografiske detaljer
Udgivet i:J Cell Sci
Main Authors: Shannon, Michael J., Pineau, Judith, Griffié, Juliette, Aaron, Jesse, Peel, Tamlyn, Williamson, David J., Zamoyska, Rose, Cope, Andrew P., Cornish, Georgina H., Owen, Dylan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614863/
https://ncbi.nlm.nih.gov/pubmed/31471459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.232991
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