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Lack of PTPN22 increases LFA-1-dependent adhesion of Murine Regulatory T Cells improving their regulatory Function

The cytoplasmic phosphatase PTPN22 (protein tyrosine phosphatase non-receptor type 22) plays a key role in regulating lymphocyte homeostasis, which ensures that the total number of lymphocytes in the periphery is kept more or less constant. Mutations in PTPN22 confer an increased risk of developing...

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Détails bibliographiques
Publié dans:Sci Signal
Auteurs principaux: Brownlie, Rebecca J, Miosge, Lisa A, Vassilakos, Demetrios, Svensson, Lena M, Cope, Andrew, Zamoyska, Rose
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836999/
https://ncbi.nlm.nih.gov/pubmed/23193160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003365
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