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Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network
Germinal centers (GCs) require sustained availability of antigens to promote antibody affinity maturation against pathogens and vaccines. A key source of antigens for GC B cells are immune complexes (ICs) displayed on follicular dendritic cells (FDCs). Here we show that FDC spatial organization regu...
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| Pubblicato in: | Nat Immunol |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2023
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614842/ https://ncbi.nlm.nih.gov/pubmed/37443283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-023-01559-1 |
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