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Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network

Germinal centers (GCs) require sustained availability of antigens to promote antibody affinity maturation against pathogens and vaccines. A key source of antigens for GC B cells are immune complexes (ICs) displayed on follicular dendritic cells (FDCs). Here we show that FDC spatial organization regu...

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Bibliografische gegevens
Gepubliceerd in:Nat Immunol
Hoofdauteurs: Martínez-Riaño, Ana, Wang, Shenshen, Boeing, Stefan, Minoughan, Sophie, Casal, Antonio, Spillane, Katelyn M, Ludewig, Burkhard, Tolar, Pavel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2023
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614842/
https://ncbi.nlm.nih.gov/pubmed/37443283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-023-01559-1
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