Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients

Pseudomonas aeruginosa is of major concern for cystic fibrosis patients where this infection can be fatal. With the emergence of drug-resistant strains, there is an urgent need to develop novel antibiotics against P. aeruginosa. MurB is a promising target for novel antibiotic development as it is in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Med Chem
Hauptverfasser: Acebrón-García-de-Eulate, Marta, Mayol-Llinàs, Joan, Holland, Matthew T. O., Kim, So Yeon, Brown, Karen P., Marchetti, Chiara, Hess, Jeannine, Di Pietro, Ornella, Mendes, Vitor, Abell, Chris, Andres Floto, R., Coyne, Anthony G., Blundell, Tom L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2022
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614804/
https://ncbi.nlm.nih.gov/pubmed/35080396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c01684
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge