Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients

Pseudomonas aeruginosa is of major concern for cystic fibrosis patients where this infection can be fatal. With the emergence of drug-resistant strains, there is an urgent need to develop novel antibiotics against P. aeruginosa. MurB is a promising target for novel antibiotic development as it is in...

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Publicado en:J Med Chem
Main Authors: Acebrón-García-de-Eulate, Marta, Mayol-Llinàs, Joan, Holland, Matthew T. O., Kim, So Yeon, Brown, Karen P., Marchetti, Chiara, Hess, Jeannine, Di Pietro, Ornella, Mendes, Vitor, Abell, Chris, Andres Floto, R., Coyne, Anthony G., Blundell, Tom L.
Formato: Artigo
Idioma:Inglês
Publicado: 2022
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614804/
https://ncbi.nlm.nih.gov/pubmed/35080396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.1c01684
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