3,5-Dioxopyrazolidines, Novel Inhibitors of UDP-N- Acetylenolpyruvylglucosamine Reductase (MurB) with Activity against Gram-Positive Bacteria

A series of 3,5-dioxopyrazolidines was identified as novel inhibitors of UDP-N-acetylenolpyruvylglucosamine reductase (MurB). Compounds 1 to 3, which are 1,2-bis(4-chlorophenyl)-3,5-dioxopyrazolidine-4-carboxamides, inhibited Escherichia coli MurB, Staphyloccocus aureus MurB, and E. coli MurA with 5...

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Autors principals: Yang, Youjun, Severin, Anatoly, Chopra, Rajiv, Krishnamurthy, Girija, Singh, Guy, Hu, William, Keeney, David, Svenson, Kristine, Petersen, Peter J., Labthavikul, Pornpen, Shlaes, David M., Rasmussen, Beth A., Failli, Amedeo A., Shumsky, Jay S., Kutterer, Kristina M. K., Gilbert, Adam, Mansour, Tarek S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2006
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366903/
https://ncbi.nlm.nih.gov/pubmed/16436710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.556-564.2006
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