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Point estimation for adaptive trial designs II: Practical considerations and guidance
In adaptive clinical trials, the conventional end‐of‐trial point estimate of a treatment effect is prone to bias, that is, a systematic tendency to deviate from its true value. As stated in recent FDA guidance on adaptive designs, it is desirable to report estimates of treatment effects that reduce...
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| Publicat a: | Stat Med |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley & Sons, Inc.
2023
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614609/ https://ncbi.nlm.nih.gov/pubmed/37021359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.9734 |
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