Llwytho...

1,4-Dideoxy-1,4-imino-d-lyxitols and L-lyxitols may bind to Golgi α-mannosidase II in a different protonation form

Development of effective inhibitors of Golgi α-manosidase II (GMII, E.C.3.2.1.114) with minimal off-target effect toward lysosomal α-manosidase (LMan, E.C.3.2.1.24) is a complex task due to complicated structural and chemical nature of their active sites. The pK(a) values (and also protonation forms...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Org Biomol Chem
Prif Awduron: Kóňa, Juraj, Šesták, Sergej, Wilson, Iain B.H., Poláková, Monika
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2022
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614232/
https://ncbi.nlm.nih.gov/pubmed/36322142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d2ob01545e
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