N-Benzyl substitution of polyhydroxypyrrolidines - the way to selective inhibitors of Golgi α-mannosidase II

Inhibition of biosynthesis of complex N-glycans in Golgi apparatus influence progress of tumor growth and metastasis. Golgi α-mannosidase II (GMII) has become a therapeutic target for a drug with anticancer activities. One critical task for successful application GMII drugs in medicine treatment is...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Šesták, Sergej, Bella, Maroš, Klunda, Tomáš, Gurská, Soňa, Džubák, Petr, Wöls, Florian, Wilson, Iain B. H., Sladek, Vladimir, Hajdúch, Marián, Poláková, Monika, Kóňa, Juraj
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6176901/
https://ncbi.nlm.nih.gov/pubmed/29323461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700607
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