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1,4-Dideoxy-1,4-imino-d-lyxitols and L-lyxitols may bind to Golgi α-mannosidase II in a different protonation form
Development of effective inhibitors of Golgi α-manosidase II (GMII, E.C.3.2.1.114) with minimal off-target effect toward lysosomal α-manosidase (LMan, E.C.3.2.1.24) is a complex task due to complicated structural and chemical nature of their active sites. The pK(a) values (and also protonation forms...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2022
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614232/ https://ncbi.nlm.nih.gov/pubmed/36322142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d2ob01545e |
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