Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals

Ferroptosis is a type of cell death caused by radical-driven lipid peroxidation, leading to membrane damage and rupture. Here we show that enzymatically produced sulfane sulfur (S(0)) species, specifically hydropersulfides, scavenge endogenously generated free radicals and, thereby, suppress lipid p...

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Yayımlandı:Nat Chem Biol
Asıl Yazarlar: Barayeu, Uladzimir, Schilling, Danny, Eid, Mohammad, Xavier da Silva, Thamara Nishida, Schlicker, Lisa, Mitreska, Nikolina, Zapp, Christopher, Gräter, Frauke, Miller, Aubry K., Kappl, Reinhard, Schulze, Almut, Friedmann Angeli, José Pedro, Dick, Tobias P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group US 2022
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613997/
https://ncbi.nlm.nih.gov/pubmed/36109647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-022-01145-w
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