Mechanoradicals in tensed tendon collagen as a source of oxidative stress

As established nearly a century ago, mechanoradicals originate from homolytic bond scission in polymers. The existence, nature and biological relevance of mechanoradicals in proteins, instead, are unknown. We here show that mechanical stress on collagen produces radicals and subsequently reactive ox...

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Publicat a:Nat Commun
Autors principals: Zapp, Christopher, Obarska-Kosinska, Agnieszka, Rennekamp, Benedikt, Kurth, Markus, Hudson, David M., Mercadante, Davide, Barayeu, Uladzimir, Dick, Tobias P., Denysenkov, Vasyl, Prisner, Thomas, Bennati, Marina, Daday, Csaba, Kappl, Reinhard, Gräter, Frauke
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210969/
https://ncbi.nlm.nih.gov/pubmed/32385229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15567-4
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