Mechanoradicals in tensed tendon collagen as a source of oxidative stress

As established nearly a century ago, mechanoradicals originate from homolytic bond scission in polymers. The existence, nature and biological relevance of mechanoradicals in proteins, instead, are unknown. We here show that mechanical stress on collagen produces radicals and subsequently reactive ox...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zapp, Christopher, Obarska-Kosinska, Agnieszka, Rennekamp, Benedikt, Kurth, Markus, Hudson, David M., Mercadante, Davide, Barayeu, Uladzimir, Dick, Tobias P., Denysenkov, Vasyl, Prisner, Thomas, Bennati, Marina, Daday, Csaba, Kappl, Reinhard, Gräter, Frauke
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210969/
https://ncbi.nlm.nih.gov/pubmed/32385229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15567-4
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