YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING

Ageing has been causally linked to the induction of cell senescence(1,2), but why this is so remains poorly understood. A key challenge is the identification of pathways that normally suppress senescence, are lost during ageing and are functionally relevant to oppose ageing(3). Here we connected the...

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Publicado no:Nature
Principais autores: Sladitschek-Martens, Hanna Lucie, Guarnieri, Alberto, Brumana, Giulia, Zanconato, Francesca, Battilana, Giusy, Xiccato, Romy Lucon, Panciera, Tito, Forcato, Mattia, Bicciato, Silvio, Guzzardo, Vincenza, Fassan, Matteo, Ulliana, Lorenzo, Gandin, Alessandro, Tripodo, Claudio, Foiani, Marco, Brusatin, Giovanna, Cordenonsi, Michelangelo, Piccolo, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613988/
https://ncbi.nlm.nih.gov/pubmed/35768505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-022-04924-6
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