Splenic red pulp macrophages provide a niche for CML stem cells and induce therapy resistance

Disease progression and relapse of chronic myeloid leukemia (CML) are caused by therapy resistant leukemia stem cells (LSCs), and cure relies on their eradication. The microenvironment in the bone marrow (BM) is known to contribute to LSC maintenance and resistance. Although leukemic infiltration of...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Bührer, Elias D., Amrein, Michael A., Forster, Stefan, Isringhausen, Stephan, Schürch, Christian M., Bhate, Salil S., Brodie, Tess, Zindel, Joel, Stroka, Deborah, Sayed, Mohamad Al, Nombela-Arrieta, César, Radpour, Ramin, Riether, Carsten, Ochsenbein, Adrian F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613762/
https://ncbi.nlm.nih.gov/pubmed/36163264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-022-01682-2
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