CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia

Aberrant proliferation, symmetric self-renewal, increased survival, and defective differentiation of malignant blasts are key oncogenic drivers in acute myeloid leukemia (AML). Stem cell gene signatures predict poor prognosis in AML patients; however, with few exceptions, these deregulated molecular...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Riether, Carsten, Schürch, Christian M., Bührer, Elias D., Hinterbrandner, Magdalena, Huguenin, Anne-Laure, Hoepner, Sabine, Zlobec, Inti, Pabst, Thomas, Radpour, Ramin, Ochsenbein, Adrian F.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5294846/
https://ncbi.nlm.nih.gov/pubmed/28031480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20152008
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