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CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression
Chronic myelogenous leukemia (CML) results from a chromosomal translocation in hematopoietic stem or early progenitor cells that gives rise to the oncogenic BCR/ABL fusion protein. Clinically, CML has a chronic phase that eventually evolves into an accelerated stage and blast crisis. A CML-specific...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266773/ https://ncbi.nlm.nih.gov/pubmed/22232214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45977 |
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