CD27 signaling on chronic myelogenous leukemia stem cells activates Wnt target genes and promotes disease progression

Chronic myelogenous leukemia (CML) results from a chromosomal translocation in hematopoietic stem or early progenitor cells that gives rise to the oncogenic BCR/ABL fusion protein. Clinically, CML has a chronic phase that eventually evolves into an accelerated stage and blast crisis. A CML-specific...

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Bibliografske podrobnosti
Main Authors: Schürch, Christian, Riether, Carsten, Matter, Matthias S., Tzankov, Alexandar, Ochsenbein, Adrian F.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266773/
https://ncbi.nlm.nih.gov/pubmed/22232214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45977
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