Circadian asthma airway responses are gated by REV-ERBα

BACKGROUND: Asthma is an inflammatory disease of the airway showing a strong time of day rhythm. Airway hyperresponsiveness is a dominant feature of asthma, but it is not known if this is under clock control. The circadian clock powerfully regulates inflammation. The clock protein REV-ERBα is known...

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Vydáno v:Eur Respir J
Hlavní autoři: Durrington, Hannah J, Krakowiak, Karolina, Meijer, Peter, Begley, Nicola, Maidstone, Robert, Goosey, Laurence, Gibbs, Julie E, Blaikley, John F, Gregory, Lisa G, Lloyd, Clare M, Loudon, Andrew SI, Ray, DW
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613655/
https://ncbi.nlm.nih.gov/pubmed/32586876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.02407-2019
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