The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

Diurnal variation in inflammatory and immune function is evident in the physiology and pathology of humans and animals, but molecular mechanisms and mediating cell types that provide this gating remain unknown. By screening cytokine responses in mice to endotoxin challenge at different times of day,...

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Detalhes bibliográficos
Main Authors: Gibbs, Julie E., Blaikley, John, Beesley, Stephen, Matthews, Laura, Simpson, Karen D., Boyce, Susan H., Farrow, Stuart N., Else, Kathryn J., Singh, Dave, Ray, David W., Loudon, Andrew S. I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258648/
https://ncbi.nlm.nih.gov/pubmed/22184247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106750109
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