The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

Diurnal variation in inflammatory and immune function is evident in the physiology and pathology of humans and animals, but molecular mechanisms and mediating cell types that provide this gating remain unknown. By screening cytokine responses in mice to endotoxin challenge at different times of day,...

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Bibliografiska uppgifter
Huvudupphovsmän: Gibbs, Julie E., Blaikley, John, Beesley, Stephen, Matthews, Laura, Simpson, Karen D., Boyce, Susan H., Farrow, Stuart N., Else, Kathryn J., Singh, Dave, Ray, David W., Loudon, Andrew S. I.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3258648/
https://ncbi.nlm.nih.gov/pubmed/22184247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106750109
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