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The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination
DNA interstrand crosslinks are tumor-inducing lesions that block DNA replication and transcription. When crosslinks are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2-FANCI clamp by the Fanconi anemia (FA) core complex. Monou...
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| Pubblicato in: | Nat Struct Mol Biol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2022
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7613635/ https://ncbi.nlm.nih.gov/pubmed/36050501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-022-00820-9 |
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