The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination

DNA interstrand crosslinks are tumor-inducing lesions that block DNA replication and transcription. When crosslinks are detected at stalled replication forks, ATR kinase phosphorylates FANCI, which stimulates monoubiquitination of the FANCD2-FANCI clamp by the Fanconi anemia (FA) core complex. Monou...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Sijacki, Tamara, Alcón, Pablo, Chen, Zhuo A., McLaughlin, Stephen H., Shakeel, Shabih, Rappsilber, Juri, Passmore, Lori A.
Format: Artigo
Sprog:Inglês
Udgivet: 2022
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613635/
https://ncbi.nlm.nih.gov/pubmed/36050501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-022-00820-9
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