Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

FANCI:FANCD2 monoubiquitination is a critical event for replication fork stabilization by the Fanconi anemia (FA) DNA repair pathway. It has been proposed that at stalled replication forks, monoubiquitinated-FANCD2 serves to recruit DNA repair proteins that contain ubiquitin-binding motifs. Here, we...

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Vydáno v:eLife
Hlavní autoři: Tan, Winnie, van Twest, Sylvie, Leis, Andrew, Bythell-Douglas, Rohan, Murphy, Vincent J, Sharp, Michael, Parker, Michael W, Crismani, Wayne, Deans, Andrew J
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Chromosomes and Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7156235/
https://ncbi.nlm.nih.gov/pubmed/32167469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54128
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