Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins

N(ε)-Methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription. The ‘highest’ methylation mark, N(ε)-trimethyllysine, is specifically recognised by N(ε)-trimethyllysine binding ‘reader’ domains, and undergoes demethylation, as catalysed by 2-oxo...

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Publicado en:Commun Chem
Autores principales: Belle, Roman, Kamps, Jos J. A. G., Poater, Jordi, Kumar, Kiran, Pieters, Bas J. G. E., Salah, Eidarus, Claridge, Timothy D. W., Paton, Robert S., Bickelhaupt, F. Matthias, Kawamura, Akane, Schofield, Christopher J., Mecinović, Jasmin
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613515/
https://ncbi.nlm.nih.gov/pubmed/36071790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42004-022-00640-4
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