Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins

N(ε)-Methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription. The ‘highest’ methylation mark, N(ε)-trimethyllysine, is specifically recognised by N(ε)-trimethyllysine binding ‘reader’ domains, and undergoes demethylation, as catalysed by 2-oxo...

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Veröffentlicht in:Commun Chem
Hauptverfasser: Belle, Roman, Kamps, Jos J. A. G., Poater, Jordi, Kumar, Kiran, Pieters, Bas J. G. E., Salah, Eidarus, Claridge, Timothy D. W., Paton, Robert S., Bickelhaupt, F. Matthias, Kawamura, Akane, Schofield, Christopher J., Mecinović, Jasmin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2022
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613515/
https://ncbi.nlm.nih.gov/pubmed/36071790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42004-022-00640-4
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