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Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins

A large number of structurally diverse epigenetic reader proteins specifically recognize methylated lysine residues on histone proteins. Here we describe comparative thermodynamic, structural and computational studies on recognition of the positively charged natural trimethyllysine and its neutral a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kamps, Jos J.A.G., Huang, Jiaxin, Poater, Jordi, Xu, Chao, Pieters, Bas J.G.E., Dong, Aiping, Min, Jinrong, Sherman, Woody, Beuming, Thijs, Matthias Bickelhaupt, F., Li, Haitao, Mecinović, Jasmin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673829/
https://ncbi.nlm.nih.gov/pubmed/26578293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9911
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