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Hydration Site Thermodynamics Explain SARs for Triazolylpurines Analogues Binding to the A2A Receptor
[Image: see text] A series of triazolylpurine analogues show interesting and unintuitive structure−activity relationships against the A2A adenosine receptor. As the 2-substituted aliphatic group is initially increased to methyl and isopropyl, there is a decrease in potency; however, extending the su...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007955/ https://ncbi.nlm.nih.gov/pubmed/24900189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100008s |
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