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Relative Binding Free Energy Calculations Applied to Protein Homology Models
A significant challenge and potential high-value application of computer-aided drug design is the accurate prediction of protein–ligand binding affinities. Free energy perturbation (FEP) using molecular dynamics (MD) sampling is among the most suitable approaches to achieve accurate binding free ene...
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| 出版年: | J Chem Inf Model |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5777225/ https://ncbi.nlm.nih.gov/pubmed/28024402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.6b00362 |
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