Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins

A large number of structurally diverse epigenetic reader proteins specifically recognize methylated lysine residues on histone proteins. Here we describe comparative thermodynamic, structural and computational studies on recognition of the positively charged natural trimethyllysine and its neutral a...

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Udgivet i:Nat Commun
Main Authors: Kamps, Jos J.A.G., Huang, Jiaxin, Poater, Jordi, Xu, Chao, Pieters, Bas J.G.E., Dong, Aiping, Min, Jinrong, Sherman, Woody, Beuming, Thijs, Matthias Bickelhaupt, F., Li, Haitao, Mecinović, Jasmin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673829/
https://ncbi.nlm.nih.gov/pubmed/26578293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9911
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