Potential disease modifying therapies for Huntington’s disease, lessons learned and future opportunities

Huntington’s disease is the most frequent autosomal dominant neurodegenerative disorder, for which we have no approved disease-modifying treatments. The molecular pathogenesis of Huntington’s disease is complex, with toxicity arising from full length expanded huntingtin and N-terminal fragments of h...

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Udgivet i:Lancet Neurol
Main Authors: Tabrizi, Sarah J, Estevez-Fraga, Carlos, van Roon-Mom, Willeke M.C., Flower, Michael D, Scahill, Rachael I, Wild, Ed J, Muñoz-Sanjuan, Ignacio, Sampaio, Cristina, Rosser, Anne E, Leavitt, Blair R.
Format: Artigo
Sprog:Inglês
Udgivet: 2022
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613206/
https://ncbi.nlm.nih.gov/pubmed/35716694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(22)00121-1
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