SWI/SNF as mechanoregulated inhibitor of YAP/TAZ

Inactivation of ARID1A and other components of the nuclear SWI/SNF protein complex occurs at exceedingly high frequency in a variety of human malignancies, suggesting a widespread role for SWI/SNF in tumor suppression. However, the underlying mechanisms remain poorly understood. Here we show that AR...

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Veröffentlicht in:Nature
Hauptverfasser: Chang, Lei, Azzolin, Luca, Biagio, Daniele Di, Zanconato, Francesca, Battilana, Giusy, Lucon Xiccato, Romy, Aragona, Mariaceleste, Giulitti, Stefano, Panciera, Tito, Gandin, Alessandro, Sigismondo, Gianluca, Krijgsveld, Jeroen, Fassan, Matteo, Brusatin, Giovanna, Cordenonsi, Michelangelo, Piccolo, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612964/
https://ncbi.nlm.nih.gov/pubmed/30401838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0658-1
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