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A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design
Orthogonal (O-) ribosome mediated translation of O-mRNAs enables the incorporation of up to three distinct non-canonical amino acids (ncAAs) into proteins in Escherichia coli. However, the general and efficient incorporation of multiple distinct ncAAs by O-ribosomes requires scalable strategies for...
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| Veröffentlicht in: | Nat Chem |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7612796/ https://ncbi.nlm.nih.gov/pubmed/34426682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-021-00764-5 |
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