Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse

DNA polymerase epsilon (Polε) carries out high fidelity leading strand synthesis owing to its exonuclease activity. Polε polymerase and exonuclease activities are balanced, due to partitioning of nascent DNA strands between catalytic sites, so that net resection occurs when synthesis is impaired. In...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Pellicanò, Grazia, Mamun, Mohammed Al, Jurado-Santiago, Dolores, Villa-Hernández, Sara, Yin, Xingyu, Giannattasio, Michele, Lanz, Michael C., Smolka, Marcus B., Yeeles, Joseph, Shirahige, Katsuhiko, García-Díaz, Miguel, Bermejo, Rodrigo
Format: Artigo
Language:Inglês
Published: 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612761/
https://ncbi.nlm.nih.gov/pubmed/33932350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.006
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