Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse

DNA polymerase epsilon (Polε) carries out high fidelity leading strand synthesis owing to its exonuclease activity. Polε polymerase and exonuclease activities are balanced, due to partitioning of nascent DNA strands between catalytic sites, so that net resection occurs when synthesis is impaired. In...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Pellicanò, Grazia, Mamun, Mohammed Al, Jurado-Santiago, Dolores, Villa-Hernández, Sara, Yin, Xingyu, Giannattasio, Michele, Lanz, Michael C., Smolka, Marcus B., Yeeles, Joseph, Shirahige, Katsuhiko, García-Díaz, Miguel, Bermejo, Rodrigo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612761/
https://ncbi.nlm.nih.gov/pubmed/33932350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.006
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