Checkpoint-mediated DNA polymerase ε exonuclease activity curbing counteracts resection-driven fork collapse

DNA polymerase epsilon (Polε) carries out high fidelity leading strand synthesis owing to its exonuclease activity. Polε polymerase and exonuclease activities are balanced, due to partitioning of nascent DNA strands between catalytic sites, so that net resection occurs when synthesis is impaired. In...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Pellicanò, Grazia, Mamun, Mohammed Al, Jurado-Santiago, Dolores, Villa-Hernández, Sara, Yin, Xingyu, Giannattasio, Michele, Lanz, Michael C., Smolka, Marcus B., Yeeles, Joseph, Shirahige, Katsuhiko, García-Díaz, Miguel, Bermejo, Rodrigo
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612761/
https://ncbi.nlm.nih.gov/pubmed/33932350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.006
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados