Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability

Problems during DNA replication underlie genomic instability and drive malignant transformation. The DNA damage checkpoint stabilizes stalled replication forks thus counteracting aberrant fork transitions, DNA breaks and chromosomal rearrangements. We analyzed fork processing in checkpoint deficient...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nucleic Acids Res
Päätekijät: Colosio, Arianna, Frattini, Camilla, Pellicanò, Grazia, Villa-Hernández, Sara, Bermejo, Rodrigo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2016
Aiheet:
Genome Integrity, Repair and Replication
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159547/
https://ncbi.nlm.nih.gov/pubmed/27672038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw858
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