Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability

Problems during DNA replication underlie genomic instability and drive malignant transformation. The DNA damage checkpoint stabilizes stalled replication forks thus counteracting aberrant fork transitions, DNA breaks and chromosomal rearrangements. We analyzed fork processing in checkpoint deficient...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Colosio, Arianna, Frattini, Camilla, Pellicanò, Grazia, Villa-Hernández, Sara, Bermejo, Rodrigo
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159547/
https://ncbi.nlm.nih.gov/pubmed/27672038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw858
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