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Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability

Problems during DNA replication underlie genomic instability and drive malignant transformation. The DNA damage checkpoint stabilizes stalled replication forks thus counteracting aberrant fork transitions, DNA breaks and chromosomal rearrangements. We analyzed fork processing in checkpoint deficient...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Colosio, Arianna, Frattini, Camilla, Pellicanò, Grazia, Villa-Hernández, Sara, Bermejo, Rodrigo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159547/
https://ncbi.nlm.nih.gov/pubmed/27672038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw858
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